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Zyban is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
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tests indicates that Zyban does not pose a genotoxic risk to humans.
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The effects of Zyban are similar to those of narcotic analgesics. Although Zyban is not classified as a narcotic, it may become habit-forming,
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Zyban has not been shown to cause histamine release. At therapeutic doses, Zyban has no effect on heart rate,
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Nalbuphine consumption in the first 24 h after operation was reduced by 35% in the Zyban group.
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Taking Zyban together with medicines that are used during surgery or dental,
since observed maximal placoncentrations after multiple oral doses are higher than expected based on single-dose data.

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Zyban is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4,
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adjustment of the dosing regimen is recommended (see  DOSAGE AND ADMINISTRATION).
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Follow your doctor's instructns for recovery.Take this medication exactly as it was prescribed for you.
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There were no other significant respiratory diffences.
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When used for long periods of time or at high doses,

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Zyban should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

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The effects of Zyban are similar to those of narcotic analgesics. Although Zyban is not classified as a narcotic, it may become habit-forming,
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The analgesic activity of Zyban is due to both parent drug and the M1 metabolite (see  CLINICAL PHARMACOLOGY, Pharmacodynamics).
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This is known as physical DEPENDENCE. If you suddenly stop taking Zyban , you may experience WITHDRAWAL symptoms including anxiety;
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Zyban has not been shown to cause histamine release. At therapeutic doses, Zyban has no effect on heart rate, left-ventricular function or cardiac index.
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Although Zyban is known to exhibit a local anaesthetic effect, how Zyban exerts this effect is not understood fully.
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